00:00 - 00:03Following our soldier preformance, we concluded
00:04 - 00:05that the brain structure
00:05 - 00:07has to be modified
00:08 - 00:12Many Hypotheses and intensive research lead us to resolve
00:12 - 00:15that we need to exclude a type of cell from the tissue
00:17 - 00:19Very well
00:19 - 00:21Proceed to a cell type screening
00:24 - 00:26My Fuhrer...
00:27 - 00:28Steiner...
00:31 - 00:33Steiner has already performed the screening
00:34 - 00:36He ordered to exclude the microglia
00:53 - 00:58Whoever didn't pass Dan's neurobiology courses, leave the room
01:13 - 01:15This is abomination
01:15 - 01:17Excluding the microglia is abomination
01:18 - 01:23Everyone should know the importance of the microglia
01:25 - 01:28Who ever say otherwise
01:29 - 01:31will be executed
01:31 - 01:34They are vital much as like the SS
01:34 - 01:37The microglia responsible for brain scavenging and cleaning
01:37 - 01:40and play a major rule in brain immunity
01:40 - 01:42My Fuhrer,they worsen injuries and infections
01:42 - 01:46You imbecile, they act as the first line of defence in those cases
01:46 - 01:48My Fuhrer, they cause cytokine storms
01:48 - 01:52What happend to you all? the brain is not just neurons
01:53 - 01:54Its a delinquent structure
01:56 - 01:57which has been
01:57 - 02:00maintained all this time
02:00 - 02:03By the most important glial cells, the microglia
02:04 - 02:08When our soldiers will suffer from head traumas
02:08 - 02:13Which cells will help engulf the infected area and protect it?!
02:14 - 02:16You all are so oblivious
02:17 - 02:21You all forgotten about the BBB? preventing the entrance of peripherial immune cells
02:27 - 02:29Without microglia...
02:30 - 02:34How can the brain fight infections and foreign bodies?
02:34 - 02:36Hell with it
02:41 - 02:42The signaling molecules
02:43 - 02:47All the signaling molecules (cytokines) that will be missed
02:48 - 02:53TNF-alpha which promotes inflammatory responses and inhibition of tumors
02:54 - 02:56So as IL1
02:56 - 02:59Also infected cells death promoted by IL1
03:00 - 03:02And IL6 which balance the inflammatory reactions
03:04 - 03:07Its ok, i missed Dan's course as well
03:14 - 03:16I'm aware of the damage they can cause..
03:19 - 03:23In Alzhiemer Disease microglia attack diseased cells resulting neurodegradation
03:25 - 03:26You've gotten fat
03:31 - 03:33Maybe you'll develop Alzhiemer (diabetes)
03:40 - 03:46Back to our subject - I know that in parkinson Disease they also damage dopaminergic cells
03:46 - 03:49But what do we care about age related diseases
03:53 - 03:56Our soldiers are young