| 00:00 - 00:03 | Following our soldier preformance, we concluded |
| 00:04 - 00:05 | that the brain structure |
| 00:05 - 00:07 | has to be modified |
| 00:08 - 00:12 | Many Hypotheses and intensive research lead us to resolve |
| 00:12 - 00:15 | that we need to exclude a type of cell from the tissue |
| 00:17 - 00:19 | Very well |
| 00:19 - 00:21 | Proceed to a cell type screening |
| 00:24 - 00:26 | My Fuhrer... |
| 00:27 - 00:28 | Steiner... |
| 00:31 - 00:33 | Steiner has already performed the screening |
| 00:34 - 00:36 | He ordered to exclude the microglia |
| 00:53 - 00:58 | Whoever didn't pass Dan's neurobiology courses, leave the room |
| 01:13 - 01:15 | This is abomination |
| 01:15 - 01:17 | Excluding the microglia is abomination |
| 01:18 - 01:23 | Everyone should know the importance of the microglia |
| 01:25 - 01:28 | Who ever say otherwise |
| 01:29 - 01:31 | will be executed |
| 01:31 - 01:34 | They are vital much as like the SS |
| 01:34 - 01:37 | The microglia responsible for brain scavenging and cleaning |
| 01:37 - 01:40 | and play a major rule in brain immunity |
| 01:40 - 01:42 | My Fuhrer,they worsen injuries and infections |
| 01:42 - 01:46 | You imbecile, they act as the first line of defence in those cases |
| 01:46 - 01:48 | My Fuhrer, they cause cytokine storms |
| 01:48 - 01:52 | What happend to you all? the brain is not just neurons |
| 01:53 - 01:54 | Its a delinquent structure |
| 01:56 - 01:57 | which has been |
| 01:57 - 02:00 | maintained all this time |
| 02:00 - 02:03 | By the most important glial cells, the microglia |
| 02:04 - 02:08 | When our soldiers will suffer from head traumas |
| 02:08 - 02:13 | Which cells will help engulf the infected area and protect it?! |
| 02:14 - 02:16 | You all are so oblivious |
| 02:17 - 02:21 | You all forgotten about the BBB? preventing the entrance of peripherial immune cells |
| 02:27 - 02:29 | Without microglia... |
| 02:30 - 02:34 | How can the brain fight infections and foreign bodies? |
| 02:34 - 02:36 | Hell with it |
| 02:41 - 02:42 | The signaling molecules |
| 02:43 - 02:47 | All the signaling molecules (cytokines) that will be missed |
| 02:48 - 02:53 | TNF-alpha which promotes inflammatory responses and inhibition of tumors |
| 02:54 - 02:56 | So as IL1 |
| 02:56 - 02:59 | Also infected cells death promoted by IL1 |
| 03:00 - 03:02 | And IL6 which balance the inflammatory reactions |
| 03:04 - 03:07 | Its ok, i missed Dan's course as well |
| 03:14 - 03:16 | I'm aware of the damage they can cause.. |
| 03:19 - 03:23 | In Alzhiemer Disease microglia attack diseased cells resulting neurodegradation |
| 03:25 - 03:26 | You've gotten fat |
| 03:31 - 03:33 | Maybe you'll develop Alzhiemer (diabetes) |
| 03:40 - 03:46 | Back to our subject - I know that in parkinson Disease they also damage dopaminergic cells |
| 03:46 - 03:49 | But what do we care about age related diseases |
| 03:53 - 03:56 | Our soldiers are young |
